THE proposed £842 million South Glasgow hospital has been given final approval.
Holyrood approved the full business case for it this week.
It will be Scotland's largest medical resource and is anticipated to transform services in Glasgow and the west.
The development will see an integrated children's and adult hospital built on the site of the current Southern General.
It will have 1,109 beds and provide maternity, paediatric and acute services on a single site.
Public health minister Shona Robison said: "Providing services for all ages on a single site will ensure patients can access the widest-possible range of specialist services and will also bring with it increased efficiency, shorter waiting times and better continuity of care".
Construction of the south hospital is scheduled to be completed in January 2015 and be fully operational by the summer of that year.
Robert Calderwood, NHS Greater Glasgow and Clyde chief executive, said: "I am delighted Holyrood has approved the full business case for the new south Glasgow hospitals.
"The project will see us complete a programme of investment of more than 1.5 billion in modern healthcare accommodation across both acute and mental health facilities".
Meanwhile, healthcare environment inspectors have published a report on the Victoria Infirmary.
Joint ward rounds to tackle infections — that are carried out by an anti-microbial pharmacist, infectious disease doctor and consultant microbiologist — at the hospital were praised.
The report found NHS Greater Glasgow and Clyde was complying with most of the standards designed to protect patients, staff and visitors from risk of infection.
But inspectors noted an inconsistent approach to cleaning between the hospital's three main buildings and called for a number of improvements.
Firstly, they want a consistent approach adopted to cleaning across the hospital. .
Secondly, inspectors want to see patient equipment is cleaned in accordance with national guidance.
And lastly, communications between staff regarding maintenance work needs to be improved.
Health secretary Nicola Sturgeon said: "The report (into the Vicky) found a number of positives but also called for various improvements.
"An action plan has already been drawn up to address these and I know that the health board is working to implement this as a matter of urgency".